Operation Christmas Child is a cool ministry through Samaritan's Purse, Franklin Graham's organization. They collect shoe boxes full of toys from people all over the US and send them out to kids in need around the world. It's a relatively easy way to give this Christmas for maximum impact. The shoe box collection week is November 12 - 19, and there are drop off locations all over the place.
For more information on how to put a box together, where you can drop yours off, etc., visit www.samaritanspurse.org/OCC_About.asp?OCCPath=1.